An association study on ADAM10 promoter polymorphisms and atherosclerotic cerebral infarction in a Chinese population.

An association study on ADAM10 promoter polymorphisms and atherosclerotic cerebral infarction in a Chinese population.
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ADAM10启动子多态性与中国人群动脉粥样硬化性脑梗塞的关联研究

DOI:
10.1111/cns.12136
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发表时间:
2013-10
影响因子:
5.5
通讯作者:
Li KS
Li KS
中科院分区:
医学1区
文献类型:
--
作者:
Li Y;Liao F;Yin XJ;Cui LL;Ma GD;Nong XX;Zhou HH;Chen YF;Zhao B;Li KS

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去整合素/金属蛋白酶ADAM10活性失调可能参与动脉粥样硬化的发生发展。虽然许多遗传学研究都集中在ADAM10基因多态性与疾病易感性的关系上,但尚未有ADAM10基因变异与动脉粥样硬化性脑梗塞(AAS)的遗传关联研究。本研究的目的是分析ADAM10启动子多态性与ACI之间的潜在关联。
Dysregulation of the activity of the disintegrin/metalloproteinase ADAM10 could contribute to the development of atherosclerosis. Although a number of genetic studies have focused on the association of ADAM10 gene polymorphisms with susceptibility to diseases, no genetic association studies of ADAM10 gene variability with atherosclerotic cerebral infarction (ACI) have been conducted. The aim of this study was to analyze the potential association between ADAM10 promoter polymorphisms and ACI.
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