Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.
Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.
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电离辐射诱导的原发性大鼠肿瘤中 c-myc 和 c-K-ras 癌基因的激活。
DOI：
10.1128/mcb.7.2.932-935.1987
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发表时间：
1987
影响因子：
5.3
通讯作者：
Garte,SJ
中科院分区：
文献类型：
--
作者：
Sawey,MJ;Hood,AT;Burns,FJ;Garte,SJ
用转染NIH 3 T3细胞和Southern印迹分析的方法，在12例电离辐射诱发的大鼠皮肤肿瘤中，6例检测到激活的K-ras癌基因。12例肿瘤中有10例的DNA也显示c-myc基因扩增和限制性内切酶多态性。在癌基因激活模式中观察到组织特异性的证据，三种透明细胞癌均表现出c-myc和K-ras癌基因的激活。
An activated K-rasoncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-mycgene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-mycand K-rasoncogenes.