Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function
Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function
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DOI：
10.1016/j.tig.2005.10.003
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发表时间：
2006-01-01
影响因子：
11.4
通讯作者：
Mattick, JS
中科院分区：
文献类型：
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作者：
Pang, KC;Frith, MC;Mattick, JS
哺乳动物的转录组中含有许多非蛋白编码RNA（ncRNA），但其中大多数意义不明，缺乏强序列保守性，提示它们可能是非功能性的。然而，某些长功能性ncRNA如Air和Xist也保守性较差。在这篇文章中，我们系统地分析了几组功能性ncRNA的保守性，包括miRNA，snoRNA和更长的ncRNA，其功能已经被记录或确信地预测。正如预期的那样，miRNAs和snoRNAs高度保守。相比之下，较长的功能性非微小、非sno ncRNA保守性要低得多，其中许多显示出快速的序列进化。我们的研究结果表明，较长的ncRNA受到不同进化限制的影响，并且数千种候选ncRNA缺乏保守性并不一定意味着缺乏功能。
The mammalian transcriptome contains many nonprotein-coding RNAs (ncRNAs), but most of these are of unclear significance and lack strong sequence conservation, prompting suggestions that they might be non-functional. However, certain long functional ncRNAs such as Air and Xist are also poorly conserved. In this article, we systematically analyzed the conservation of several groups of functional ncRNAs, including miRNAs, snoRNAs and longer ncRNAs whose function has been either documented or confidently predicted. As expected, miRNAs and snoRNAs were highly conserved. By contrast, the longer functional non-micro, non-sno ncRNAs were much less conserved with many displaying rapid sequence evolution. Our findings suggest that longer ncRNAs are under the influence of different evolutionary constraints and that the lack of conservation displayed by the thousands of candidate ncRNAs does not necessarily signify an absence of function.