Paneth-like cells in renal cell carcinomas and in cysts associated with acquired cystic kidney disease: Clinicopathologic analysis, comparative study and description of precursor lesions
Paneth-like cells in renal cell carcinomas and in cysts associated with acquired cystic kidney disease: Clinicopathologic analysis, comparative study and description of precursor lesions
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DOI：
10.1016/j.anndiagpath.2021.151707
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发表时间：
2021-01-27
影响因子：
2
通讯作者：
Hes, Ondrej
中科院分区：
文献类型：
--
作者：
Kojima, Fumiyoshi;Alaghehbandan, Reza;Hes, Ondrej
Paneth样细胞(PLC)不同于Paneth细胞(PC)，含有Paneth样颗粒，在非肿瘤条件下和在各种器官的肿瘤中已有报道。在肾透明细胞癌(CcRCC)中已有报道，但在非CcRCC中未见报道，包括获得性囊性疾病相关性肾细胞癌(ACD-RCC)。我们分析了24例伴有PLC的获得性囊性疾病相关性肾细胞癌(ACD-RCCP+)的临床病理特征，并与23例无PLC的ACD-RCCP-进行了比较。大约一半的ACD-RCC有PLC，并且几乎所有含有ACD-RCC的肾脏都有带有PLC的囊肿。许多ACD-RCC和囊肿伴PLC的事实进一步证明，具有空泡和复杂结构的囊肿可能是ACD-RCC的前驱病变。在肾脏获得性囊性疾病的鉴别诊断中，PLC的存在可能为鉴别ACD-RCC和PRCC提供额外的形态学线索。
Paneth-like cells (PLCs) are different from Paneth cells (PCs) and contain Paneth-like granules, which have been reported in non-neoplastic conditions and in neoplasms of various organs. PLCs have been reported in clear cell renal cell carcinoma (CCRCC), but not in non-CCRCC, including acquired cystic disease?associated renal cell carcinoma (ACD-RCC). We analyzed clinicopathological features of 24 acquired cystic disease?associated renal cell carcinoma (ACD-RCC) with PLCs (ACD-RCCP+) and compared with those of 23 ACD-RCCs without PLCs (ACD-RCCP-). Approximately half of ACD-RCCs had PLCs and that almost all kidneys harboring ACD-RCC had cysts with PLCs. The fact that many ACD-RCCs and the cysts had PLCs is further evidence that the cyst with vacuoles and complex architecture might be a precursor lesion for ACD-RCC. The presence of PLCs may provide additional morphologic clue for distinguishing ACD-RCC from PRCC in challenging differential diagnostic workup in acquired cystic disease of the kidney setting.