The first, second and third wave of pandemic influenza A (H1N1)pdm09 in North Denmark Region 2009-2011: a population-based study of hospitalizations
The first, second and third wave of pandemic influenza A (H1N1)pdm09 in North Denmark Region 2009-2011: a population-based study of hospitalizations
复制标题
DOI：
10.1111/irv.12093
复制
发表时间：
2013-09-01
影响因子：
4.4
通讯作者：
Nielsen, Henrik
中科院分区：
文献类型：
--
作者：
Orsted, Iben;Molvadgaard, Mette;Nielsen, Henrik
背景和目标 丹麦从 2009 年 7 月至 2011 年 2 月经历了三波新的甲型流感 (H1N1)pdm09 大流行。本研究的目的是描述丹麦北部地区特定人群住院患者的流行病学和临床特征，该地区是一个城乡混合社区，共有 579 000 名居民。方法 回顾 7 月份以来所有确诊甲型流感住院患者的医疗记录 2009年至2011年2月。 结果 273例患者入院。与年龄相关的人群住院发生率如下：0-14岁：111/100000，15-64岁：39/100000，≥65岁：17/100 000。在第一波期间（2009年7月至2009年8月），收治了三名患者，没有人在重症监护病房（ICU）接受治疗。第二波（2009年10月至2010年1月），收治158名患者 - 9 人在 ICU 接受治疗，在第三波期间（2010 年 12 月至 2011 年 2 月），收治了 112 名患者 - 25 人在 ICU 接受治疗。 14 名患者 (5%) 在诊断后 30 天内死亡（中位 55 岁；范围 14-76 岁），另外 7 名患者 (2.6%) 在 365 天内死亡（中位 25 年；范围 1-86 岁）。 结论 因甲型流感 (H1N1)pdm09 住院的患者主要是儿童和年轻人，只有少数患者年龄 >65 岁。考虑到入住 ICU 的患者数量和百分比以及 30 天死亡率，第三波疫情最为严重。我们观察到，从第二波到第三波，年轻人的住院发生率和临床严重程度没有下降。
Background and objectives Denmark experienced three waves of the new pandemic influenza A (H1N1)pdm09 from July 2009 to February 2011. The aim of the study was to describe the epidemiology and clinical characteristics of hospitalized patients in a defined population of North Denmark Region with a mixed urban and rural community of 579 000 inhabitants.Methods Review of medical records of all hospitalized patients with confirmed influenza A from July 2009 to February 2011.Results Two hundred and seventy-three patients were admitted to hospital. The age-related population incidences of hospitalization were as follows: 0-14years: 111/100000, 15-64years: 39/100000, and >= 65years: 17/100 000. During the first wave (July 2009-August 2009), three patients were admitted - none received treatment in intensive care units (ICUs), during the second wave (October 2009-January 2010), 158 patients were admitted - nine received treatment in ICUs, and during the third wave (December 2010-February 2011), 112 patients were admitted - 25 received treatment in ICUs. Fourteen patients (5%) died within 30days of diagnosis (median 55 years; range 14-76 years) and additional seven patients (2.6%) died within 365days (median 25years; range 1-86 years).Conclusions Patients hospitalized with pandemic influenza A (H1N1)pdm09 were predominantly children and younger adults, and only a few patients were >65 years. The third wave was the most severe taking the number and percentage of patients admitted to ICUs and 30-day mortality into consideration. We observed that the incidence of hospitalizations as well as clinical severity among younger adults did not decline from the second to the third wave.