Significance thresholds for quantitative trait locus mapping under selective genotyping
Significance thresholds for quantitative trait locus mapping under selective genotyping
复制标题
DOI：
10.1534/genetics.107.080093
复制
发表时间：
2007-11-01
期刊：
影响因子：
3.3
通讯作者：
Broman, Karl W.
中科院分区：
文献类型：
--
作者：
Manichaikul, Ani;Palmer, Abraham A.;Broman, Karl W.
在选择性基因分型的情况下，通常的排列测试，以建立数量性状基因座（QTL）定位的统计显着性可能会给出不适当的显着性阈值，特别是当表型分布是偏斜的。应使用分层排列检验，在基因分型和未分型个体中分别进行表型改组。
In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals.