ACTIVATION OF BROWN ADIPOSE-TISSUE THERMOGENESIS IN RECOVERY FROM ANESTHETIC HYPOTHERMIA IN RATS
ACTIVATION OF BROWN ADIPOSE-TISSUE THERMOGENESIS IN RECOVERY FROM ANESTHETIC HYPOTHERMIA IN RATS
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DOI：
10.1152/ajpregu.1991.261.2.r301
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发表时间：
1991-08-01
影响因子：
--
通讯作者：
SAITO, M
中科院分区：
文献类型：
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作者：
SHIMIZU, Y;SAITO, M
通过测量大鼠肩胛间 BAT 和直肠的温度或组织对 2-脱氧葡萄糖 (2-DG) 的摄取，研究了麻醉低温恢复过程中棕色脂肪组织 (BAT) 产热的变化。 腹腔注射戊巴比妥钠（50 mg/kg）后，直肠温度下降至约33℃的稳定水平（稳定期），然后逐渐升高（恢复期）。 恢复期肩胛间BAT温度明显高于直肠温度。 BAT体内2-DG的摄取在稳定期较低，但在恢复期大幅增加。 手术去交感神经支配后或当直肠温度维持在约 37.5 摄氏度时，2-DG 摄取的增加受到抑制。 在心脏、骨骼肌和白色脂肪组织中，除了心脏略有增加外，2-DG 摄取没有明显变化。 β-肾上腺素能阻断减弱了恢复阶段观察到的 BAT 温度和 2-DG 摄取的变化。 结论是，BAT 对麻醉低温恢复过程中产热有显着贡献。
Changes of brown adipose tissue (BAT) thermogenesis in the recovery from anesthetic hypothermia were studied by measuring the temperatures of the interscapular BAT and rectum or the tissue uptake of 2-deoxyglucose (2-DG) in rats. After intraperitoneal injection of pentobarbital sodium (50 mg/kg), rectal temperature decreased to reach a steady level of approximately 33-degrees-C (steady phase) and then increased gradually (recovery phase). The temperature of the interscapular BAT was significantly higher than rectal temperature in the recovery phase. The uptake of 2-DG in vivo in BAT was low in the steady phase but increased greatly in the recovery phase. The increase in 2-DG uptake was suppressed after surgical sympathetic denervation or when rectal temperature was maintained at approximately 37.5-degrees-C. In the heart, skeletal muscle, and white adipose tissue, there was no appreciable change in 2-DG uptake except a slight increase in the heart. beta-Adrenergic blockade attenuated the changes in BAT temperature and 2-DG uptake seen during the recovery phase. It was concluded that BAT significantly contributes to heat production in recovery from anesthetic hypothermia.