Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.
Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.
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同源结构域相互作用蛋白激酶 2 (HIPK2)：一个有希望的抗癌治疗靶点
DOI：
10.18632/oncotarget.14723
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发表时间：
2017-03-21
期刊：
影响因子：
--
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Feng Y;Zhou L;Sun X;Li Q
HIPK 2（丝氨酸/苏氨酸同源结构域相互作用蛋白激酶2）是一种“看守”基因，其失活增加致瘤性，而其活化抑制肿瘤生长。本文综述了HIPK 2的抗肿瘤作用机制，包括促进细胞凋亡、抑制缺氧条件下的血管生成、抑制肿瘤侵袭转移和减弱肿瘤多药耐药等。此外，我们总结了可能增加HIPK 2活性的条件或因素。
The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a “caretaker” gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angiogenesis in hypoxia, prevention of tumor invasion/metastasis and attenuation of multidrug resistance in cancer. Additionally, we summarize conditions or factors that may increase HIPK2 activity.
影响因子：
3.7
作者：
Ma X;Liu JX
通讯作者：
Liu JX