The relative role of transplacental and milk immune transfer in protection against lethal neonatal herpes simplex virus infection in mice.
The relative role of transplacental and milk immune transfer in protection against lethal neonatal herpes simplex virus infection in mice.
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经胎盘和乳汁免疫转移在预防小鼠致命性新生儿单纯疱疹病毒感染中的相对作用。
DOI：
10.1093/infdis/149.1.38
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Loo,LS
中科院分区：
文献类型：
--
作者：
Kohl,S;Loo,LS
母体被动免疫在新生儿单纯疱疹病毒(HSV)感染中的作用存在争议。单纯疱疹病毒免疫母亲所生的C57BL/6小鼠在经腹膜内或口服单纯疱疹病毒感染后的存活率显著高于非免疫母亲所生的小鼠。在随后的经腹和口服HSV攻击的实验中，由主动或被动免疫的母亲寄养了一周的非免疫小鼠得到了显著的保护。非免疫母鼠产后注射被动抗体，可通过母乳将HSV抗体转移到仔鼠体内。在小鼠中，母亲的母乳，而不是胎盘衍生的抗体，保护新生儿免受低剂量HSV感染。
The role of passive maternal immunity in neonatal herpes simplex virus (HSV) infection is controversial. C57BL/6 mice born to HSV-immune mothers had significantly greater survival than those born to nonimmune mothers after an intraperitoneal or oral HSV challenge. In subsequent experiments with intraperitoneal and oral HSV challenge, nonimmune mice that were foster fed for one week by actively or passively immunized mothers were significantly protected. Injections of passive antibody postpartum in nonimmune mother mice resulted in detectable transfer of antibody to HSV to their infant mice via breast milk. In mice, maternal breast milk, not transplacentally derived antibody, protects neonates from low-dose HSV infection.