Photopic 30 Hz flicker electroretinography predicts ocular neovascularization in central retinal vein occlusion.
Photopic 30 Hz flicker electroretinography predicts ocular neovascularization in central retinal vein occlusion.
复制标题
明视 30 Hz 闪烁视网膜电图可预测视网膜中央静脉阻塞中的眼部新生血管形成。
作者：
Ole Kjeka;C. Bredrup;J. Krohn
目的
目的探讨30 Hz闪烁视网膜电图（30 Hz flicker electroretinography，ERG）明视锥b波隐式时间对视网膜中央静脉阻塞（central retinal vein occlusion，CRVO）患者眼新生血管（ocular neovascularization，NV）的预测价值，并与假定健康对侧眼进行比较。
方法
71例连续CRVO患者的回顾性分析。在ERG检查后，所有患者随访至少12个月，或直到发现NV。3例患者在研究期间死亡，其他患者均未失访。
结果
24例患者（33.8%）在随访期间发生NV。所有患者的平均锥体b波隐式时间为32.6 ms [标准差（SD）5.21]。所有18名患者的隐式时间为35.0 ms或更高（与平均值相差> 0.5 SD），均发生NV。发生NV患者的平均隐式时间为38.5 ms（范围29.7-43.9 ms），无NV患者（n = 47）的平均隐式时间为29.6 ms（范围24.7-34.9 ms）（P < 0.0001）。NV患者的假定健康对侧眼的平均内隐时间为28.7 ms（范围24.4-33.9 ms），无NV患者为26.5 ms（范围23.7-33.2 ms）（P = 0.002）。NV患者眼内隐时间平均差异为9.9ms（4.1- 15.7ms），而无NV患者眼内隐时间平均差异为2.9ms（-1.0 ~10.0ms）（P < 0.0001）。
结论
CRVO患者应常规进行明视30 Hz闪烁ERG检查，这是一种简单客观的临床测试，可以识别有眼部NV风险的患者。假设使用所提供的ERG设置，35.0 ms或更高的隐式时间（与平均值相差> 0.5 SD）与眼NV的发生明显相关。将患眼的ERG结果与假定健康的对侧眼进行比较可能价值不大。
PURPOSE
To confirm the predictive value of photopic cone b-wave implicit time in 30 Hz flicker electroretinography (ERG) for ocular neovascularization (NV) in central retinal vein occlusion (CRVO), and to compare the ERG results to the presumed healthy fellow eye.
METHODS
A retrospective analysis of 71 consecutive patients with CRVO. After ERG examination, all patients were followed for at least 12 months, or until NV was found. Three patients died during the study period; none of the other patients were lost to follow-up.
RESULTS
Twenty-four patients (33.8%) developed NV during follow-up. The mean cone b-wave implicit time of all patients was 32.6 ms [standard deviation (SD) 5.21]. All 18 patients with an implicit time of 35.0 ms or higher (> 0.5 SD from mean) developed NV. In patients who developed NV, the average implicit time was 38.5 ms (range 29.7-43.9 ms); in patients without NV (n = 47), the average implicit time was 29.6 ms (range 24.7-34.9 ms) (P < 0.0001). The average implicit time in the presumed healthy fellow eye was 28.7 ms (range 24.4-33.9 ms) in patients with NV, and 26.5 ms (range 23.7-33.2 ms) in patients without NV (P = 0.002). The mean interocular difference in implicit time was 9.9 ms (range 4.1-15.7 ms) in patients with NV and 2.9 ms (range -1.0 to 10.0 ms) in patients without NV (P < 0.0001).
CONCLUSION
Patients with CRVO should be examined routinely with photopic 30 Hz flicker ERG, which is a simple and objective clinical test that can identify patients at risk of ocular NV. On the assumption that the presented ERG settings are used, implicit times of 35.0 ms or higher (> 0.5 SD from mean) are clearly associated with the development of ocular NV. To compare the ERG result of the affected eye to the presumed healthy fellow eye is probably of less value.
使用闪烁视网膜电图预测视网膜中央静脉阻塞的结果。
DOI：
10.1001/archopht.1993.01090080119027
发表时间：
1993
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Severns,ML;Johnson,MA
通讯作者：
Johnson,MA