PREPULSE INHIBITION OF ACOUSTIC STARTLE, A MEASURE OF SENSORIMOTOR GATING - EFFECTS OF ANTIPSYCHOTICS AND OTHER AGENTS IN RATS
PREPULSE INHIBITION OF ACOUSTIC STARTLE, A MEASURE OF SENSORIMOTOR GATING - EFFECTS OF ANTIPSYCHOTICS AND OTHER AGENTS IN RATS
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DOI：
10.1016/0091-3057(95)00160-x
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发表时间：
1995-12-01
影响因子：
3.6
通讯作者：
SVENSSON, L
中科院分区：
文献类型：
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作者：
JOHANSSON, C;JACKSON, DM;SVENSSON, L
精神分裂症患者缺乏反映信息处理的各种神经学指标。其中一种测量方法是声音惊吓的前脉冲抑制（PPI），其中精神分裂症患者表现出比正常受试者更少的抑制。PPI在用拟精神病药物如安非他明和苯环利定治疗的大鼠中也减少。PPI已被建议作为研究精神分裂症的病理生理学相关的模型。我们研究了各种抗精神病药物和推定的抗精神病药物和一些关键的参考化合物对声惊吓反应（ASR）和PPI的影响。一些，但不是所有的，抗精神病药物测试（主要是选择性多巴胺D-2拮抗剂）增强PPI。雷莫必利和氯氮平都是抗精神病药，而非常有效和高度选择性的D1拮抗剂NCQ-298则没有。可以得出结论，在其他未经处理的大鼠增强PPI并不反映抗精神病疗效。我们进一步注意到，对PPI的影响与对ASR的影响无关。
Schizophrenic patients are deficient in various neurologic measures reflecting information processing. One such measure is prepulse inhibition (PPI) of acoustic startle, in which schizophrenics display less inhibition than normal subjects. PPI is also diminished in rats treated with psychotomimetic drugs such as amphetamine and phencyclidine. PPI has been suggested as a model relevant for studying the pathophysiology of schizophrenia. We studied the effect of a variety of antipsychotics and putative antipsychotics and some key reference compounds on the acoustic startle response (ASR) and PPI. Some, but not all, antipsychotics tested (mainly selective dopamine D-2 antagonists) enhanced PPI. Remoxipride and clozapine, both of which are antipsychotics, and the very potent and highly selective D, antagonist, NCQ-298, did not. It is concluded that enhanced PPI in otherwise untreated rats does not reflect antipsychotic efficacy. We further noted that the effect on PPI was independent of the effect on ASR.