Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992
Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992
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DOI：
10.1001/archderm.133.6.735
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发表时间：
1997-06-01
影响因子：
--
通讯作者：
Roenigk, RK
中科院分区：
文献类型：
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作者：
Gray, DT;Suman, VJ;Roenigk, RK
目的：研究皮肤浸润性鳞状细胞癌（SCC）首次诊断的发病率随时间的变化。设计：回顾性，以人群为基础的发病率研究。设置：由马约诊所及其附属医院和奥姆斯特德医学中心（包括其在明尼苏达州罗切斯特的附属医院）提供服务的经计数的、地理隔离的、半城市人群。方法：使用罗切斯特流行病学项目数据库，该数据库几乎捕获了为罗切斯特居民提供的所有医疗护理，我们确定并审查了所有记录在案的居民的记录，皮肤的侵袭性SCC在1984年和1992年之间首次被诊断。计算了特定于年龄和性别阶层的比率，并使用Poisson回归分析了35岁或以上个体随时间推移观察到的年龄调整比率。调整率进行了比较，与其他研究的结果。结果：审查1630记录确定511例SCC的发病率。肿瘤位于头颈部，女性占66.4%，男性占72.9%。每10万人的年年龄和性别特异性发病率从0 - 14岁男性的0例增加到85岁或以上男性的1286.0例。随着时间的推移，每10万名女性的年年龄调整发病率从46.5（95%置信区间[CI]，32.4-60.6）从1984年至1986年期间的99.6（95% CI，80.4-118.7），总体为71.2（95% CI，61.7-80.8）。男性的相应发生率为125.9（95% CI，95.3-156.4）、191.0（95% CI，156.9-225.0）和155.5（95% CI，137.0-174.0）。1987 - 1989年和1990 - 1992年年龄和性别校正的SCC发病率高于1984 - 1986年（P= 0.03和P
Objective: To examine the incidence of first diagnosis of invasive squamous cell carcinoma (SCC) of the skin over time.Design: Retrospective, population-based incidence study.Setting: Enumerated, geographically isolated, semiurban population served by the Mayo Clinic and its affiliated hospitals and the Olmsted Medical Center, including its affiliated hospital in Rochester, Mim.Methods: Using the Rochester Epidemiology Project databases that capture virtually all medical care provided to the residents of Rochester, we identified and reviewed records of all documented residents in whom histologically proven, invasive SCC of the skin was first diagnosed between 1984 and 1992. Age and sex stratum-specific rates were calculated, and age-adjusted rates observed over time for individuals aged 35 years or older were analyzed using Poisson regression. Adjusted rates were compared with the results of other studies.Results: Review of 1630 records identified 511 incidence cases of SCC. Tumors located on the:head nd neck accounted for 66.4% of tumors in females and 72.9% in males. The annual age- and sex-specific incidence rates per 100 000 increased from 0 cases among males aged 0 to 14 years to 1286.0 cases among males aged 85 years or older. Over time, the annual age-adjusted incidence rates per 100 000 females rose from 46.5 (95% confidence interval [CI], 32.4-60.6) for the 1984 to 1986 period to 99.6 (95% CI, 80.4-118.7) for the 1990 to 1992 period and were 71.2 (95% CI, 61.7-80.8) overall. The corresponding rates for males were 125.9 (95% CI, 95.3-156.4), 191.0 (95% CI, 156.9-225.0), and 155.5 (95% CI, 137.0-174.0). The age- and sex-adjusted SCC incidence rates for the period from 1987 to 1989 and 1990 to 1992 exceeded those for the period from 1984 to 1986 (P=.03 and P