Agreement of self reported use of menopausal hormone replacement therapy with physician reports
Agreement of self reported use of menopausal hormone replacement therapy with physician reports
复制标题
DOI：
10.1097/00001648-199905000-00012
复制
发表时间：
1999-05-01
期刊：
影响因子：
5.4
通讯作者：
Howe, GR
中科院分区：
文献类型：
--
作者：
Jain, MG;Rohan, TE;Howe, GR
相对较少的流行病学研究来验证从研究参与者那里获得的关于更年期激素替代疗法使用的信息。我们将这项研究作为1994-1998年间加拿大安大略省多伦多市饮食、激素使用和子宫内膜癌病例对照研究的一部分。我们比较了653名年龄在30-79岁的受试者的记录，与他们的医生关于曾经/从未使用激素替代疗法以及激素替代疗法的持续时间、类型和剂量的报告进行了比较。共有88%的访谈记录与医生关于曾经/从未使用激素替代疗法的报告一致。激素替代治疗持续时间的总体Kappa值为0.76(范围=0.71-0.81)，组内相关系数为0.64(范围=0.57-0.70)，表明一致性良好；在总体使用以及单独使用雌激素或孕激素的病例和对照组中也发现了类似的相关性。约43%的受试者观察到品牌代码的一致性。这项研究表明，在病例对照研究中通过访谈获得的信息为激素替代疗法的使用和使用时间提供了合理的衡量标准。然而，采访并不代表激素替代疗法制剂的品牌和剂量信息的可靠来源。
There have been relatively few epidemiological studies to verify the information obtained from study participants on the use of menopausal hormone replacement therapy. We con ducted this study as part of a case-control study of diet, hormone use, and endometrial cancer in Toronto, Ontario, Canada, ada, 1994-1998. We compared records from 653 subjects, 30-79 years of age, with reports from their physicians on ever/never use of hormone replacement therapy and duration, type, and dose of hormone replacement therapy. A total of 88% of the interview records were in agreement with physician reports for ever/never use of hormone replacement therapy. The overall kappa value for ever/never use agreement was 0.76 (range = 0.71-0.81), and the intraclass correlation coefficient was 0.64 (range = 0.57-0.70) for duration of hormone replacement therapy use, indicating good agreement; similar correlations were seen among cases and controls for overall use, as well as estrogen- or progestogen-alone use. Concordance for brand codes was observed for about 43% of the subjects. This study suggests that information obtained by interview in case-control studies provides a reasonable measure of ever use of hormone replacement therapy and duration of use. Interviews, however, do not represent a reliable sourer of information on brands and dosage of hormone replacement therapy preparations.