Identification of dihydropyridines that reduce cellular tau levels
Identification of dihydropyridines that reduce cellular tau levels
复制标题
DOI：
10.1039/c0cc02253e
复制
发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Gestwicki, Jason E.
中科院分区：
文献类型：
--
作者：
Evans, Christopher G.;Jinwal, Umesh K.;Gestwicki, Jason E.
鉴定了一系列二氢吡啶类化合物，它们对阿尔茨海默病的重要靶点tau的积累有影响。使用Hantzsch多组分反应扩展了二氢吡啶的收集，以建立初步的结构-活性关系。
A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.