BIOASSAY-DIRECTED CHEMICAL-ANALYSIS IN ENVIRONMENTAL-RESEARCH
BIOASSAY-DIRECTED CHEMICAL-ANALYSIS IN ENVIRONMENTAL-RESEARCH
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DOI：
10.1021/ac00124a001
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发表时间：
1986-09-01
影响因子：
7.4
通讯作者：
LEWTAS, J
中科院分区：
文献类型：
--
作者：
SCHUETZLE, D;LEWTAS, J
对能对人类健康或生态产生影响的特定化合物的研究是环境和健康科学的一个主要研究目标。环境污染对人类健康的影响，包括致突变和致癌作用，是一个主要问题。癌症是各种肿瘤疾病的总称，这些疾病可能在接触致癌物质多年后发生。消除癌症的最好方法是精确地确定致癌化学物质、化学物质混合物或环境中产生癌症的增强因素的性质。20世纪60年代早期的生物测定研究表明，香烟烟雾和环境空气微粒等环境混合物可导致动物癌症。人们进行了广泛的研究，以确定可能造成这种影响的化学成分。人们发现，大多数环境样品在化学上是复杂的，由数千种化合物组成
Reseach of specific chemi-cal compounds that can produce hu-man health or ecological effects is a major research objective in environmental and health sciences. The impact of environmental pollution on human health, including mutagenic and carcinogenic effects, is a primary concern. Cancer is a generic term for various neoplastic diseases that can occur many years after exposure to a carcinogenic substance. The best means of eliminating cancer is to de-fine precisely the nature of the carci-nogenic chemical, mixture of chemi-cals, or enhancing factors in the envi-ronment that produce the cancer(1). Bioassay studies in the early 1960s showed that environmental mixtures such as cigarette smoke and ambient air particulates can cause cancer in animals. Extensive studies were un-dertaken to determine the chemical components that could be responsible for such an effect. It was found that most environmental samples were chemically complex and comprised of thousands of chemical compounds