A program for solving the brain ischemia problem.
A program for solving the brain ischemia problem.
复制标题
DOI：
10.3390/brainsci3020460
复制
发表时间：
2013-04-08
期刊：
影响因子：
3.3
通讯作者：
DeGracia DJ
中科院分区：
文献类型：
--
作者：
DeGracia DJ
我们最近描述的细胞损伤的非线性动力学模型在这里被应用于脑缺血和神经保护的问题。我们讨论了测量全脑缺血损伤动力学的时程分析。使用模型参数的假设值来模拟所提出的实验的解决方案。该解决方案解决了全球脑缺血问题的“主分叉图”，显示了所有致命的脑血流量（CBF）递减的任意持续时间的所有可能的结果。全脑缺血主分叉图：（1）可以映射到单个局灶性缺血损伤，（2）显示所有对神经保护敏感的CBF减少。我们模拟测量神经保护剂的时间过程分析，揭示了紧急的非线性效应，设置动态限制神经保护。使用过度简化的行程几何形状，我们计算出理论最大保护约为50%的恢复。我们还计算了在实践中可能获得的结果，并获得了38%的回收率;这个数字接近文献中经常报道的数字。这里研究的假设的例子说明了使用的非线性细胞损伤模型作为一种新的途径的方法，有潜力，不仅解决脑缺血的问题，而且还推进神经保护技术。
Our recently described nonlinear dynamical model of cell injury is here applied to the problems of brain ischemia and neuroprotection. We discuss measurement of global brain ischemia injury dynamics by time course analysis. Solutions to proposed experiments are simulated using hypothetical values for the model parameters. The solutions solve the global brain ischemia problem in terms of “master bifurcation diagrams” that show all possible outcomes for arbitrary durations of all lethal cerebral blood flow (CBF) decrements. The global ischemia master bifurcation diagrams: (1) can map to a single focal ischemia insult, and (2) reveal all CBF decrements susceptible to neuroprotection. We simulate measuring a neuroprotectant by time course analysis, which revealed emergent nonlinear effects that set dynamical limits on neuroprotection. Using over-simplified stroke geometry, we calculate a theoretical maximum protection of approximately 50% recovery. We also calculate what is likely to be obtained in practice and obtain 38% recovery; a number close to that often reported in the literature. The hypothetical examples studied here illustrate the use of the nonlinear cell injury model as a fresh avenue of approach that has the potential, not only to solve the brain ischemia problem, but also to advance the technology of neuroprotection.