Proposed Criteria for Metabolic Syndrome in Japanese Based on Prospective Evidence The Hisayama Study
Proposed Criteria for Metabolic Syndrome in Japanese Based on Prospective Evidence The Hisayama Study
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DOI：
10.1161/strokeaha.108.531319
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发表时间：
2009-04-01
期刊：
影响因子：
8.3
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
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作者：
Doi, Yasufumi;Ninomiya, Toshiharu;Kiyohara, Yutaka
背景和目的-代谢综合征(METS)的现行标准不是基于心血管疾病(CVD)前瞻性研究的证据。方法：在一项对2452名40岁的日本社区居民进行的14年跟踪研究中，我们研究了哪些METS标准对心血管疾病的发展最具预测性。结果：预测心脑血管疾病的最佳腰围截断点为男性90 cm(年龄调整危险比=1.81；95%可信区间1.19~2.74；P=0.005)和女性80 cm(年龄调整危险比=1.46；95%可信区间0.99~2.16；P=0.05)。与METS标准的比较显示，修改后的日本标准使用这个截断点而不是原来的定义，是男女心血管事件的最强预测因子(男性：年龄调整后的危险比=2.58；95%CI，1.65至4.02；P
Background and Purpose-The current criteria of metabolic syndrome (MetS) are not based on evidence derived from prospective studies on cardiovascular disease (CVD).Methods-In a 14-year follow-up study of 2452 community-dwelling Japanese individuals aged >= 40 years, we examined which of the MetS criteria are most predictive for the development of CVD. During the follow-up, 246 first-ever CVD events occurred.Results-An optimal cutoff point of waist circumference for predicting CVD was 90 cm in men (age-adjusted hazard ratio= 1.81; 95% CI, 1.19 to 2.74; P=0.005) and 80 cm in women (age-adjusted hazard ratio= 1.46; 95% CI, 0.99 to 2.16; P = 0.05). A comparison of MetS criteria showed that the modified Japanese criteria using this cutoff point instead of the original definition were the strongest predictor of CVD events in both sexes (men: age-adjusted hazard ratio=2.58; 95% CI, 1.65 to 4.02; P