CLINICAL EFFECT OF HUMAN PITUITARY FOLLICLE-STIMULATING HORMONE (FSH)
CLINICAL EFFECT OF HUMAN PITUITARY FOLLICLE-STIMULATING HORMONE (FSH)
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DOI：
10.1210/jcem-18-12-1333
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发表时间：
1958-01-01
影响因子：
5.8
通讯作者：
TILLINGER, G
中科院分区：
文献类型：
--
作者：
GEMZELL, CA;DICZFALUSY, E;TILLINGER, G
部分纯化的促卵泡激素制剂（人垂体FSH）已从人垂体中获得。对7例闭经妇女的卵巢反应进行了研究。此外，还研究了人绒毛膜促性腺激素（HCG）的作用。在4例子宫内膜无活动或仅轻度增生的患者中，单独使用HCG不诱导排卵，对子宫大小、子宫内膜或尿中雌激素和孕激素排泄无影响。在2例子宫内膜增生的患者中，单独使用HCG后排卵，子宫内膜分泌转化，尿妊娠激素排泄明显增加。对2例患者单独给予人垂体FSH导致子宫腔大小增加，卵巢多囊增大，尿雌激素分泌明显增加。用人垂体FSH治疗，然后用HCG治疗，所有患者的卵巢均出现多囊性增大，5例中有4例排卵，5例中有3例子宫内膜分泌性转化。排卵伴随着雌激素和孕激素的尿排泄量显着增加。
A partially purified follicle-stimulating hormone preparation (human pituitary FSH) has been obtained from human pituitaries. The ovarian response to this preparation was studied in 7 amenorrheic women. The effect of human chorionic gonadotropin (HCG) was studied in addition. In 4 patients exhibiting no endometrial activity or only slight proliferation, HCG alone did not induce ovulation and had no effect on the size of the uterus, on the endometrium, or on the urinary excretion of estrogen and pregnanediol. In 2 patients showing endometrial proliferation, the administration of HCG alone was followed by ovulation, a secretory transformation of the endometrium, and a marked increase in urinary pregnanediol excretion. The administration of human pituitary FSH alone to 2 patients resulted in an increase in the size of the uterine cavity, in polycystic enlargement of the ovaries, and in a pronounced increase in urinary estrogen output. Treatment with human pituitary FSH followed by HCG produced in all patients polycystic enlargement of the ovaries, ovulation in 4 out of 5, and a secretory transformation of the endometrium in 3 out of these 5 patients. Ovulation was accompanied by a marked increase in the urinary excretion of both estrogen and pregnanediol.