MicroRNA-105 targets SOX9 and inhibits human glioma cell progression
MicroRNA-105 targets SOX9 and inhibits human glioma cell progression
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MicroRNA-105 靶向 SOX9 并抑制人胶质瘤细胞进展
DOI：
10.1002/1873-3468.12458
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发表时间：
2016-12-01
期刊：
影响因子：
3.5
通讯作者：
Zhang, Shizhong
中科院分区：
文献类型：
--
作者：
Liu, Xiyao;Wang, Huiqing;Zhang, Shizhong
越来越多的证据表明microRNA（miRNA）通过直接调控多个靶点在胶质瘤的发展中发挥重要作用。在此，我们发现在胶质瘤组织中miR-105表达显著降低，并且与SOX 9 mRNA表达呈负相关。S 0X 9被鉴定为miR-105的直接靶标。miR-105的上调抑制了SOX 9、TCF 4、c-MYC、cyclin D1和AXIN 2的表达，并抑制了胶质瘤细胞的进展。S 0X 9或TCF 4的恢复消除了miR-105对胶质瘤细胞进展的作用。SOX 9下调与miR-105上调对胶质瘤进展的作用相似。此外，TCF 4恢复挽救了SOX 9下调对胶质瘤进展的影响。总之，这些发现表明miR-105通过调节胶质瘤中的SOX 9/TCF 4轴而作为潜在的肿瘤抑制剂发挥作用。
Growing evidence indicates that microRNA (miRNA) play vital roles in glioma progression by directly regulating multiple targets. Here, we found that miR-105 expression was significantly decreased and inversely correlated with SOX9 mRNA expression in glioma tissues. SOX9 was identified as a direct target of miR-105. miR-105 up-regulation repressed the expression of SOX9, TCF4, c-MYC, cyclin D1, and AXIN2 and suppressed glioma cell progression. Restoration of SOX9 or TCF4 abolished the effect of miR-105 on glioma cell progression. SOX9 down-regulation had similar effects as miR-105 up-regulation on glioma progression. Moreover, TCF4 restoration rescued the effect of SOX9 down-regulation on glioma progression. Altogether, these findings suggested that miR-105 functions as a potential tumor suppressor by regulating the SOX9/TCF4 axis in glioma.