Viridepyronone, a new antifungal 6-substituted 2H-pyran-2-one produced by Trichoderma viride
Viridepyronone, a new antifungal 6-substituted 2H-pyran-2-one produced by Trichoderma viride
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DOI：
10.1021/jf034708j
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发表时间：
2003-11-19
影响因子：
6.1
通讯作者：
Motta, A
中科院分区：
文献类型：
--
作者：
Evidente, A;Cabras, A;Motta, A
从一株绿色木霉（Trichoderma viride）的培养滤液中分离得到一种新的6-取代-2H-吡喃-2-酮（viridepyronone），该化合物对朝鲜蓟冠、茎腐病的病原菌白绢病（Sclerotium rolfsii）具有拮抗活性。用光谱方法确定了Viridepyronone的结构为6-（4-oxopentyl）-2H-吡喃-2-酮2。生物活性测定结果表明，绿地吡酮对沙门氏菌有较好的抑菌活性。rolfsii，并且发现其最小抑制浓度（超过90%抑制）为196 μ g/mL。这是首次报道任何种类的真菌产生的viridepyronone。
A new antifungal 6-substituted 2H-pyran-2-one, named viridepyronone, has been isolated from a cultural filtrate of a strain of Trichoderma viride showing antagonistic activity in vitro toward Sclerotium rolfsii, which is the causal agent of crown and stem rot of artichoke. Viridepyronone was characterized as 6-(4-oxopentyl)-2H-pyran-2-one 2 with spectroscopic methods. Bioassays showed that viridepyronone had a good antifungal activity against S. rolfsii, and its minimum inhibitory concentration (over 90% inhibition) was found to be 196 mug/mL. This is the first report of viridepyronone produced by any species of fungi.