Shifting Prevalence of Major Diarrheal Pathogens in Patients Seeking Hospital Care during Floods in 1998, 2004, and 2007 in Dhaka, Bangladesh

Shifting Prevalence of Major Diarrheal Pathogens in Patients Seeking Hospital Care during Floods in 1998, 2004, and 2007 in Dhaka, Bangladesh
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DOI:
10.4269/ajtmh.2008.79.708
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发表时间:
2008-11-01
影响因子:
3.3
通讯作者:
Qadri, Firdausi
Qadri, Firdausi
中科院分区:
医学4区
文献类型:
--
作者:
Harris, Aaron M.;Chowdhury, Fahima;Qadri, Firdausi

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2007年,孟加拉国经历了严重的洪水和疟疾流行。我们比较了2007年、2004年和1998年在达卡ICDDR B医院就诊的疟疾患者的洪水数据。在2007年,霍乱弧菌OI(33%),轮状病毒(42%)和肠致病性大肠杆菌(ETEC)(12%)是最流行的。与2004年和1998年相比,2007年脱水更严重(P < 0.001)。在2007年,发现了霍乱弧菌OI Inaba(52%)和Ogawa(48%),而在2004年和1998年,分别主要是Inaba和Ogawa型(P < 0.001)。2007年产热不稳定毒素(LT)的ETEC占51%(与2004年相比P < 0.001),产热稳定毒素(ST)的ETEC占22%(与2004年相比P < 0.001)。ST/LT阳性率为27%(P = 0.231)。CS 7定植因子(CF)在2007年最普遍(20%,2004年为6%; P = 0.05)。我们的研究结果表明,在最近的孟加拉国洪水的主要细菌病原体的临床特征和表型变化的改变。
Bangladesh experienced severe flooding and diarrheal epidemics in 2007. We compared flood data from 2007 with 2004 and 1998 for diarrheal patients attending the ICDDR,B hospital in Dhaka. In 2007, Vibrio cholerae OI (33%), rotavirus (42%), and enterotoxigenic Escherichia coli (ETEC) (12%) were most prevalent. More severe dehydration was seen in 2007 compared with 2004 and 1998 (P < 0.001). In 2007, V. cholerae OI Inaba (52%) and Ogawa (48%) were seen, whereas in 2004 and 1998 it was primarily Inaba and the Ogawa types, respectively (P < 0.001). In 2007, 51% of ETEC produced the heat labile toxin (LT) (P < 0.001 compared with 2004), 22% expressed the heat stable (ST) (P < 0.001). and 27% were ST/LT positive (P = 0.231). The CS7 colonization factor (CF) was the most prevalent in 2007 (20% compared with 6% in 2004; P = 0.05). Our findings demonstrate alterations in clinical features and phenotypic changes of major bacterial pathogens in the recent Bangladesh flood.