Functional requirement for class I MHC in CNS development and plasticity
Functional requirement for class I MHC in CNS development and plasticity
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DOI：
10.1126/science.290.5499.2155
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发表时间：
2000-12-15
期刊：
影响因子：
56.9
通讯作者：
Shatz, CJ
中科院分区：
文献类型：
--
作者：
Huh, GS;Boulanger, LM;Shatz, CJ
I类主要组织相容性复合物（I类MHC）分子，已知对于抗原的免疫应答是重要的，也由经历活性依赖性、长期结构和突触修饰的神经元表达。在这里，我们表明，在遗传缺陷的小鼠细胞表面I类MHC或I类MHC受体成分，CD 3 ζ，细化视网膜和中央目标之间的连接在发展过程中是不完整的。在成年突变体的海马中，N-甲基-D-天冬氨酸受体依赖的长时程增强（LTP）增强，而长时程抑制（LTD）缺失。特定的I类MHC信使RNA由不同的神经元镶嵌体表达，反映了不同神经元功能的潜力。这些结果表明，这些分子在发育和成熟的哺乳动物中枢神经系统（CNS）的活动依赖性重塑和可塑性的连接中的重要作用。
Class I major histocompatibility complex (class I MHC) molecules, known to be important for immune responses to antigen, are expressed also by neurons that undergo activity-dependent, Long-term structural and synaptic modifications. Here, we show that in mice genetically deficient for cell surface class I MHC or for a class I MHC receptor component, CD3 zeta, refinement of connections between retina and central targets during development is incomplete. In the hippocampus of adult mutants, N-methyl-D-aspartate receptor-dependent Long-term potentiation (LTP) is enhanced, and Long-term depression (LTD) is absent. Specific class I MHC messenger RNAs are expressed by distinct mosaics of neurons, reflecting a potential for diverse neuronal functions. These results demonstrate an important role for these molecules in the activity-dependent remodeling and plasticity of connections in the developing and mature mammalian central nervous system (CNS).