Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma
Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma
复制标题
10p12.31、10q21.1 和 13q12.13 的常见变异与散发性垂体腺瘤相关。
DOI：
10.1038/ng.3322
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发表时间：
2015-07-01
期刊：
影响因子：
30.8
通讯作者：
Zhao, Yao
中科院分区：
文献类型：
--
作者：
Ye, Zhao;Li, Zhiqiang;Zhao, Yao
Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 x 10(-8)) in the combined analyses: 10p12.31 (rs2359536, P-meta = 2.25 x 10(-10) and rs10828088, P-meta = 6.27 x 10(-10)), 10q21.1 (rs10763170, P-meta = 6.88 x 10(-10)) and 13q12.13 (rs17083838, P-meta = 1.89 x 10(-8)). This study is the first GWAS to our knowledge on sporadic pituitary adenoma, and our results provide insight into the genetic basis of this disease.
