Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes.
Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes.
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DOI：
10.1016/j.ics.2005.07.090
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发表时间：
2005-11-01
期刊：
影响因子：
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通讯作者：
Alkana, R L
中科院分区：
文献类型：
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作者：
Davies, D L;Kuo, S T;Alkana, R L
The current study investigated the effects of propofol on P2X4 receptors expressed in Xenopus oocytes using two-electrode voltage clamp. We also tested the effects of 100 mM ethanol on the same oocytes used to test propofol. Propofol potentiated ATP-gated currents in a concentration dependent manner in P2X4 receptors. In agreement with our previous findings, ethanol inhibited P2X4 receptors. The opposite effects of propofol and ethanol on P2X4 receptor function suggest that these anesthetics act via different sites/mechanisms in P2X receptors as has been suggested for GABA(A) and glycine receptors.
