Evaluating elements of executive functioning as predictors of instrumental activities of daily living (IADLs)
Evaluating elements of executive functioning as predictors of instrumental activities of daily living (IADLs)
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DOI：
10.1016/j.acn.2006.03.007
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发表时间：
2006-05-01
影响因子：
2.6
通讯作者：
Cohen, Ronald A.
中科院分区：
文献类型：
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作者：
Jefferson, Angela L.;Paul, Robert H.;Cohen, Ronald A.
目的：执行功能已被多次联系到工具性日常生活活动（IADL）的完整性。本研究探讨了多个执行功能元素（即，工作记忆、产生、抑制、计划和排序）对IADL的影响。72名患有流行但稳定的心血管疾病的参与者完成了一项神经心理学方案，评估执行功能的多个要素，包括COWA，PASAT，DKEFS颜色词干扰测试，DKEFS线索制作测试，DKEFS塔测试，和Ruff图形流畅性测试。结果：逐步逻辑回归选择了一个模型，涉及一个单一的显着预测，抑制措施（即，DKEFS色词干扰测验），其具有显著的回归系数。随后的相关性分析证实了抑制措施和多个IADL项目之间的关联。IADL之间的项目间比较显示出显着差异，如电话使用和洗衣显着更完整的比大多数其他IADL，而购物和家务是最compromised.CONCLUSIONS：我们的数据表明，抑制，也被称为干扰的敏感性，是最强烈的相关性IADL障碍的患者在未来的认知和功能下降的风险。(c)2006年美国国家神经心理学学会。由爱思唯尔有限公司出版。保留所有权利。
OBJECTIVE: Executive functioning has been repeatedly linked to the integrity of instrumental activities of daily living (IADL). The present study examined the association of multiple executive functioning elements (i.e., working memory, generation, inhibition, planning, and sequencing) to IADLs among an older adult cohort at risk for future cognitive and functional decline.METHODS: Seventy-two participants with prevalent but stable cardiovascular disease completed a neuropsychological protocol assessing multiple elements of executive functioning, including COWA, PASAT, DKEFS Color-Word Interference Test, DKEFS Trail-Making Test, DKEFS Tower Test, and Ruff Figural Fluency Test. Reliable informants completed a measure of IADLs.RESULTS: Stepwise logistic regression selected a model involving a single significant predictor, a measure of inhibition (i.e., DKEFS Color-Word Interference Test), which had a significant regression coefficient. Subsequent correlation analyses confirmed an association between the inhibition measure and multiple IADL items. Inter-item comparisons among the IADLs revealed significant differences, such that telephone use and laundry were significantly more intact than most other IADLs while shopping and housekeeping were most compromised.CONCLUSIONS: Our data suggest that inhibition, also known as susceptibility to interference, is most strongly related to IADL impairment among patients at risk for future cognitive and functional decline. (c) 2006 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.