HYALURONATE INHIBITION OF CELL-PROLIFERATION
HYALURONATE INHIBITION OF CELL-PROLIFERATION
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DOI：
10.1002/art.1780300707
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发表时间：
1987-07-01
影响因子：
--
通讯作者：
TOOLE, BP
中科院分区：
文献类型：
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作者：
GOLDBERG, RL;TOOLE, BP
通过向培养基中添加透明质酸来抑制细胞培养物中兔滑膜细胞、3T3细胞或猿病毒转化的3T3细胞的增殖。这种效果明显取决于透明质酸盐的分子量和浓度。在正常滑液中存在的透明质酸的分子量和浓度下，增殖受到抑制。在类风湿滑液中发现，在较低的分子量或浓度下，透明质酸盐的抑制作用明显减弱。因此，与关节病相关的滑液透明质酸盐的变化可能有助于为类风湿性血管翳扩张创造有利的环境。
The proliferation of rabbit synovial cells, 3T3 cells, or simian virus-transformed 3T3 cells in cell culture was inhibited by the addition of hyaluronate to the culture medium. This effect was markedly dependent on the molecular weight and concentration of the hyaluronate. At the molecular weight and concentration of hyaluronate present in normal synovial fluid, proliferation was inhibited. At lower molecular weights or concentrations, as found in rheumatoid synovial fluid, hyaluronate was significantly less inhibitory. Thus, the changes in synovial fluid hyaluronate that are associated with arthropathies may contribute to a favorable environment for rheumatoid pannus expansion.