Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer
Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer
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DOI：
10.1007/s10637-008-9145-0
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发表时间：
2009-04-01
影响因子：
3.4
通讯作者：
Vali, Mustafa
中科院分区：
文献类型：
--
作者：
Buijs, Manon;Vossen, Josephina A.;Vali, Mustafa
目的：通过测定治疗剂量静脉给药后的FDG摄取，评价3-BrPA对荷RMT乳腺肿瘤大鼠的抗糖酵解作用。材料和方法：用溶于2.5 ml PBS的15 mM 3-BrPA或2.5 ml PBS处理16只携带RMT肿瘤的大鼠。治疗后，所有大鼠接受FDG，并在1h后处死。结果：3-BrPA治疗显著降低肿瘤中FDG摄取77%（p = 0.002）。治疗后正常组织的FDG摄取没有显著降低。结论：3-BrPA对大鼠移植的RMT细胞具有较强的抗糖酵解作用。
Purpose: To evaluate the anti-glycolytic effects of 3-BrPA on rats bearing RMT mammary tumors, by determining FDG uptake after intravenous administration of the therapeutic dose. Materials and Methods: Sixteen rats bearing RMT tumors were treated either with 15 mM 3-BrPA in 2.5 ml of PBS or with 2.5 ml of PBS. After treatment, all rats received FDG and were sacrificed 1 h later. Results: 3-BrPA treatment significantly decreased FDG uptake in tumors by 77% (p = 0.002). FDG uptake did not significantly decrease in normal tissues after treatment. Conclusion: Our study showed that 3-BrPA exhibits a strong anti-glycolytic effect on RMT cells implanted in rats.