Restricted number of chromosomal regions implicated in aetiology of human cancer and leukaemia
Restricted number of chromosomal regions implicated in aetiology of human cancer and leukaemia
复制标题
与人类癌症和白血病病因学有关的染色体区域数量有限
作者：
F. Mitelman
自Boveri时代以来，人们就知道肿瘤与染色体畸变有关。大约10年前，染色体显带技术的引入为描述大量的这种畸变以及将畸变背后的断裂定位于单个染色体带提供了动力。假设，断裂应该包括两种本质上不同的类型：主动参与恶性发展的原发性断裂，以及与该过程巧合的继发性断裂。在寻找一种可能的方法来识别人类癌症中的原发性断裂时，我从现有的染色体畸变目录中选择了那些有一个单一结构畸变作为其唯一偏离正常的病例。我在这里报告，这样指定的断裂点影响的染色体区域的数量令人惊讶地有限，并得出结论，这些区域包含的基因的首要重要性癌症的发展。
It has been known since the days of Boveri1 that neoplasia is associated with chromosomal aberration. The introduction, some 10 years ago, of chromosome banding techniques provided the impetus for the description of an immense number of such aberrations, and for the localization to individual chromosome bands of the breaks underlying the aberrations. Hypothetically, the breaks should comprise two essentially different kinds: primary breaks that are actively involved in the malignant development, and secondary breaks, coincidental to this process. In the search for a possible method to identify primary breaks in human cancer, I selected from the catalogue of chromosome aberrations now available2 those cases that had one single structural aberration as their sole deviation from normality. I report here that the breakpoints thus specified affect a surprisingly limited number of chromosomal regions, and conclude that these regions contain genes of prime importance to cancer development.