Intracranial EEG Recordings of High-Frequency Activity From a Wireless Implantable BMI Device in Awake Nonhuman Primates
Intracranial EEG Recordings of High-Frequency Activity From a Wireless Implantable BMI Device in Awake Nonhuman Primates
复制标题
DOI：
10.1109/tbme.2022.3210286
复制
发表时间：
2023-04-01
影响因子：
4.6
通讯作者：
Hirata，Masayuki
中科院分区：
文献类型：
--
作者：
Yan，Tianfang;Suzuki，Katsuyoshi;Hirata，Masayuki
目的：无线植入式脑机接口（bmi）是一种很有前途的恢复重度运动障碍患者通信和运动功能的工具。在临床应用之前，必须通过动物实验充分证实记录性能。在本文中，我们旨在评估一种用于记录两种非人类灵长类动物大脑活动的新型BMI无线设备的性能。方法自制一种无线植入式bmi装置，用于临床应用。我们使用电池而不是无线充电系统。在左侧颞顶叶皮层硬膜下植入32个电极。我们通过听觉稳态反应（ASSRs）和氯胺酮诱导反应来评估无线设备的记录性能。结果该装置成功地记录了两只清醒猕猴颞叶皮层高频波段的宽带振荡活动。原始信号的频谱分析表明，该装置检测到40 hz ASSR的特征结果和氯胺酮注射引起的显著高频带活性。结论无线设备在记录和传输皮质电图（ECoG）信号方面具有毫秒精度和记录稳定性。这些结果提供了信心，这种无线设备可以在自由运动模型中成为其他基础神经科学研究的转化工具。
ObjectiveWireless implantable brain machine interfaces (BMIs) are a promising tool to restore communication and motor functions for individuals with severe motor disability. Prior to clinical application, recording performance must be sufficiently confirmed by animal experiments. In this paper, we aimed to evaluate the performance of a novel BMI wireless device for recording brain activity in two nonhuman primates.MethodWe customized a wireless device for implantable BMIs for clinical application. We used a battery instead of a wireless power charging system. Thirty-two electrodes were subdurally implanted over the left temporoparietal cortex. We evaluated the recording performance of the wireless device by auditory steady-state responses (ASSRs) and ketamine-induced responses.ResultThe devices successfully recorded broadband oscillatory activities up to the high-frequency band from the temporal cortex in two awake macaque monkeys. Spectral analysis of raw signals demonstrated that the devices detected characteristic results of a 40-Hz ASSR and prominent high-frequency band activity induced by ketamine injection.ConclusionWe confirmed the functionality of the wireless device in recording and transmitting electrocorticography (ECoG) signals with both millisecond precision and recording stability.SignificanceThese results provide confidence that this wireless device can be a translational tool for other fundamental neuroscientific studies in free-moving models.