Copper(II)-Catalyzed Direct Dioxygenation of Alkenes with Air and N-Hydroxyphthalimide: Synthesis of β-Keto-N-alkoxyphthalimides
Copper(II)-Catalyzed Direct Dioxygenation of Alkenes with Air and N-Hydroxyphthalimide: Synthesis of β-Keto-N-alkoxyphthalimides
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DOI：
10.1021/acs.orglett.5b00770
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发表时间：
2015-04-17
期刊：
影响因子：
5.2
通讯作者：
Punniyamurthy, Tharmalingam
中科院分区：
文献类型：
--
作者：
Bag, Raghunath;Sar, Dinabandhu;Punniyamurthy, Tharmalingam
铜 (II) 催化的烯烃使用空气和简单的 N-羟基邻苯二甲酰亚胺直接双氧化反应生成 β-酮基-N-烷氧基邻苯二甲酰亚胺。该反应体系温和、高效、室温有效，底物范围广，空间位阻大。自由基捕获和 O-18 标记实验已得到证实。
Copper(II)-catalyzed direct dioxygenation of alkenes using air and a simple N-hydroxyphthalimide leading to beta-keto-N-alkoxyphthalimides has been developed. The reaction system is mild, efficient, and effective at room temperature with broad substrate scope and substantial steric hindrance. The radical-trapping and O-18-labeling experiments have been demonstrated.