Do different ADHD-related etiological risks involve specific neuropsychological pathways? An analysis of mediation processes by inhibitory control and delay aversion.
Do different ADHD-related etiological risks involve specific neuropsychological pathways? An analysis of mediation processes by inhibitory control and delay aversion.
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不同的 ADHD 相关病因风险是否涉及特定的神经心理学途径？
DOI：
10.1111/jcpp.12059
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Becker
中科院分区：
文献类型：
--
作者：
Pauli-Pott;Mingebach;Roller;Becker
背景抑制控制（inhibitorycontrol，IC）被认为是一种神经心理学基础缺陷，是注意缺陷多动障碍（attentiondeficithyperactivitydisorder，ADHD）的一种内表型。这里涉及的是病因因素和ADHD症状之间的中介过程。因此，我们分析执行IC和延迟厌恶（DA;即，奖励相关的IC）性能介导的协会的家庭，产前，和心理社会风险与ADHD symptoms.MethodsThe研究样本包括130名学龄前儿童（3-6岁，50%的男孩），包括20%（n= 26）与ADHD的阳性家族史（家族风险）。产前风险主要来自医疗记录。通过结构化访谈评估心理社会风险。ADHD症状通过结构化访谈和由家长和教师完成的问卷进行评估。一组神经心理学任务IC和DA进行了与children.ResultsFamilial，产前，和心理社会风险与ADHD症状显着相关。IC和DA也与ADHD症状显著相关。虽然家族性风险与IC和DA显著相关，但心理社会和产前风险与这些措施仅弱相关。家族性风险和ADHD症状之间的联系部分介导IC和DA。ConclusionsThe结果表明不同的神经心理通路相关的“积极的ADHD家族史”和产前风险。考虑到未来研究的交叉验证，结果强调了学龄前IC和DA的内在表型特征。
BackgroundInhibitory control (IC) has been regarded as a neuropsychological basic deficit and as an endophenotype of attention deficit/hyperactivity disorder (ADHD). Implicated here are mediation processes between etiological factors and ADHD symptoms. We thus analyze whether and to what extent executive IC and delay aversion (DA; i.e., reward‐related IC) performance mediate the associations of familial, prenatal, and psychosocial risks with ADHD symptoms.MethodsThe study sample consisted of 130 preschool children (3–6 years; 50% boys), including 20% (n= 26) with a positive family history of ADHD (familial risk). Prenatal risks were mainly taken from medical records. Psychosocial risks were assessed by a structured interview. ADHD symptoms were assessed by structured interviews and questionnaires completed by parents and teachers. A set of neuropsychological tasks on IC and DA was conducted with the children.ResultsFamilial, prenatal, and psychosocial risks were significantly associated with ADHD symptoms. IC and DA also correlated significantly with ADHD symptoms. While the familial risk significantly correlated with IC and DA, psychosocial and prenatal risks were only weakly associated with these measures. The link between the familial risk and ADHD symptoms was partially mediated by IC and DA.ConclusionsThe results indicate different neuropsychological pathways related to ‘positive family history of ADHD’ and prenatal risks. Given a cross‐validation in future studies, the results underscore the endophenotypic character of IC and DA in preschool ages.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1016/j.jaac.2011.09.007
发表时间：
2011-12-01
影响因子：
13.3
作者：
Groen-Blokhuis, Maria M.;Middeldorp, Christel M.;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.
注意力缺陷多动障碍的家庭环境危险因素。
影响因子：
--
作者：
Biederman,J;Milberger,S;Faraone,SV;Kiely,K;Guite,J;Mick,E;Ablon,S;Warburton,R;Reed,E
通讯作者：
Reed,E
DOI：
10.1111/j.1469-7610.2008.01928.x
发表时间：
2008-09
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
S. Loo;Erika Carpenter Rich;Janeen Ishii;J. McGough;J. McCracken;S. Nelson;S. Smalley
通讯作者：
S. Loo;Erika Carpenter Rich;Janeen Ishii;J. McGough;J. McCracken;S. Nelson;S. Smalley
ADHD内表型与表型的关系
影响因子：
5.1
作者：
N. Rommelse;M. Altink;N. Martin;C. Buschgens;S. Faraone;J. Buitelaar;J. Sergeant;J. Oosterlaan
通讯作者：
J. Oosterlaan