Hyaluronan as a therapeutic target in human diseases.
Hyaluronan as a therapeutic target in human diseases.
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DOI：
10.1016/j.addr.2015.10.017
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发表时间：
2016-02-01
影响因子：
16.1
通讯作者：
Noble PW
中科院分区：
文献类型：
--
作者：
Liang J;Jiang D;Noble PW
细胞外基质的积聚和周转是人类疾病组织损伤、修复和重塑的标志。透明质酸是细胞外基质的主要成分，在调节组织损伤和修复以及控制疾病转归方面发挥着重要作用。透明质酸的功能取决于它的大小、位置和与结合伙伴的相互作用。虽然碎片化的透明质酸通过调节炎症反应和组织修复的各种细胞类型刺激一系列基因的表达，但细胞表面的透明质酸提供了保护，防止环境对组织的破坏，并促进再生和修复。透明质酸与其结合蛋白的相互作用参与了许多人类疾病的发病过程。因此，靶向透明质酸及其与细胞和蛋白质的相互作用可能为开发炎性和纤维化疾病的治疗方法提供新的途径。本文综述了透明质酸在生物和病理过程中的作用，以及作为人类疾病潜在治疗靶点的研究进展。
Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix and plays an important role in regulating tissue injury and repair, and controlling disease outcomes. The function of hyaluronan depends on its size, location, and interactions with binding partners. While fragmented hyaluronan stimulates the expression of an array of genes by a variety of cell types regulating inflammatory responses and tissue repair, cell surface hyaluronan provides protection against tissue damage from the environment and promotes regeneration and repair. The interactions of hyaluronan and its binding proteins participate in the pathogenesis of many human diseases. Thus, targeting hyaluronan and its interactions with cells and proteins may provide new approaches to developing therapeutics for inflammatory and fibrosing diseases. This review focuses on the role of hyaluronan in biological and pathological processes, and as a potential therapeutic target in human diseases.