Protective effects of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice
Protective effects of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice
复制标题
DOI：
10.1111/j.1742-7843.2004.950305.x
复制
发表时间：
2004-09-01
影响因子：
3.1
通讯作者：
Hassoun, EA
中科院分区：
文献类型：
--
作者：
Alsharif, NZ;Hassoun, EA
研究了维生素A和琥珀酸维生素E对2,3,7,8-四氯二苯并-对二恶英（TCDD）急性毒性的保护作用及氧化应激措施。10只小鼠分别接受维生素A（每隔一天50 mg/kg，连续8天）或维生素E琥珀酸（150 mg/kg/天，然后再给40 mg/kg/天，连续5天）治疗。上述各组各有一半动物在第4天接受TCDD治疗。5只小鼠单独注射玉米油或TCDD。在TCDD治疗5天后，与单独TCDD相比，维生素A和TCDD或维生素E琥珀酸盐和TCDD抗氧化联合治疗可显著降低急性毒性指标，包括全身和胸腺重量的减少(P
The protective effect of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced acute toxicity and measures of oxidative stress was studied. Ten mice were treated with either vitamin A (50 mg/kg every other day for eight days) or vitamin E succiante (150 mg/kg/day followed by a dose of 40 mg/kg/day for five additional days). Half of each of the above groups of animals received TCDD on day 4. Five mice received corn oil or TCDD alone. After five days of TCDD treatment, antioxidant combination treatment with vitamin A and TCDD or vitamin E succinate and TCDD resulted in a significant reduction in indicators of acute toxicity including the decrease in total body and thymus weight as compared to TCDD alone (P