Tumor Acidity/NIR Controlled Interaction of Transformable. Nanoparticle with Biological Systems for Cancer Therapy
Tumor Acidity/NIR Controlled Interaction of Transformable. Nanoparticle with Biological Systems for Cancer Therapy
复制标题
肿瘤酸度/近红外控制的可转化的相互作用。
DOI：
10.1021/acs.nanolett.6b05396
复制
发表时间：
2017-05-01
期刊：
影响因子：
10.8
通讯作者：
Wang, Jun
中科院分区：
文献类型：
--
作者：
Li, Dongdong;Ma, Yinchu;Wang, Jun
精确控制纳米粒子与生物系统从注射部位到生物靶点的相互作用（纳米生物相互作用）显示出巨大的生物医学应用潜力。受纳米颗粒根据不同刺激改变其物理化学性质的能力的启发，我们探索了肿瘤酸度和近红外（NIR）光激活的可转化纳米颗粒（DA）TAT-NPIR&DOX。该纳米颗粒由肿瘤酸度激活的达特[达特赖氨酸残基的胺用2，3-二甲基马来酸酐（DA）修饰]、共封装NIR染料IR-780的柔性链聚磷酸酯核心和DOX（多柔比星）组成：可以使用肿瘤酸度和NIR光以逐步方式控制纳米颗粒的物理化学性质，从而产生可调节的纳米生物相互作用。由于血液循环期间达特肽的掩蔽，所得的可转化纳米颗粒（DA）TAT-NPIR&DOX有效地避免了与单核吞噬细胞系统（MPS）的相互作用（“隐形”状态）。一旦它在肿瘤组织中积累，（DA）TAT-NPIR&DOX就会被肿瘤酸性重新激活，并依次转化为“识别”状态。以促进与肿瘤细胞的相互作用并增强细胞内化。然后，这种纳米粒子在近红外辐射下转变为“攻击”状态，实现了柔性链聚磷酸酯：核心的超灵敏DOX释放，以增加DOX-DNA相互作用。这一概念为创造具有控制纳米生物相互作用能力的可转化药物递送系统提供了新的途径。
Precisely controlling the interaction of nanoparticles with biological systems (nanobio interactions) from the injection site to biological targets shows great potential for biomedical applications. Inspired by the ability of nanoparticles to alter, their physicochemical properties according to different stimuli, we-explored the tumor acidity and near-infrared (NIR) light activated transformable nanoparticle (DA)TAT-NPIR&DOX. This nanoparticle consists of a tumor acidity-activated TAT [the TAT lysine residues' amines was modified with 2,3-dimethylmaleic anhydride (DA)], a flexible chain polyphosphoester core coencapsulated a NIR dye IR-780, and DOX (doxorubicin): The physicochemical properties of the nanoparticle can be controlled in a stepwise fashion using tumor acidity and NIR light, resulting in adjustable nanobio interactions. The resulting transformable nanoparticle (DA)TAT-NPIR&DOX efficiently avoids the interaction with mononuclear phagocyte system (MPS) ("stealth" state) due to the masking of the TAT peptide during blood circulation. Once it has accumulated in the tumor tissues, (DA)TAT-NPIR&DOX is reactivated by tumor acidity and transformed into the "recognize" state in order. to promote interaction with tumor cells and enhance cellular internalization. Then, this nanoparticle is transformed into "attack" state under NIR irradiation, achieving the-supersensitive DOX release from the flexible chain polyphosphoester :core in order to increase the DOX-DNA interaction. This concept provides new avenues for the creation of transformable drug delivery systems that have the ability to control nanobio interactions.