A controlled technique for the employment of naturally induced malaria in the therapy of paresis
A controlled technique for the employment of naturally induced malaria in the therapy of paresis
复制标题
DOI：
10.1093/oxfordjournals.aje.a117909
复制
发表时间：
1933-01-01
影响因子：
--
通讯作者：
Stratman-Thomas, WK
中科院分区：
文献类型：
--
作者：
Boyd, MF;Stratman-Thomas, WK
在10个月的过程中，一株间日疟原虫经历了6次连续的按蚊-人完全传代。这项技术需要可靠地供应未受感染的[雌性]按蚊，最好是实验室培育的;从适当病人身上提取的一种间日疟原虫，它将产生中等强度的感染;小心地保存受感染的蚊子;全面记录每批蚊子，解剖自然死亡的蚊子，以确定每批蚊子感染的大致定性发生率;以及将2只受感染的蚊子应用于患者，以确保疟疾的临床发作持续数周。对于身体状况较好和新入院的患者，治疗更成功。成年的黑人对接种毫无抵抗力。疟疾的临床病程和自发终止的可能性与所用受感染蚊子的数量有关。
In the course of 10 mos., one strain of Plasmodium vivax experienced 6 successive complete anopheline-human pas sages. The technique requires a dependable supply of uninfected [female] anophelines, preferably laboratory bred; a strain of Plasmodium vivax from a suitable patient, which will produce an infection of moderate intensity; careful conservation of the infected mosquitoes; a comprehensive record of the mosquitoes in each lot and the dissection of those which die a natural death to determine the approximate qualitative incidence of infection in a lot; and the application of 2 infected mosquitoes to the patient in order to insure a clinical attack of malaria extending over several weeks. The therapy is more successful on patients in good physical condition and newly hospitalized. Adult negroes are decidedly re-fractory to inoculation. The clinical course of malaria and the possibility of spontaneous termination are related to the number of infected mosquitoes applied.