Dentin regeneration in vitro: the pivotal role of supportive cells.
Dentin regeneration in vitro: the pivotal role of supportive cells.
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DOI：
10.1177/0022034511405324
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发表时间：
2011-07-01
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通讯作者：
About, I
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文献类型：
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作者：
About, I
牙本质-牙髓工程策略的制定不仅需要研究祖细胞的潜能，还需要研究它们与其他非祖细胞“支持”细胞的相互作用。在严重龋损的情况下，龋损牙本质酸性溶解后释放的生长因子可能会激活祖细胞。然而，在创伤后也观察到牙本质再生，但没有任何明显的牙本质溶解。这就提出了有关祖细胞激活、迁移和分化所涉及的信号来源的问题。研究模型，如全牙培养和牙髓与内皮细胞的共培养，强调了不同牙髓细胞类型之间的相互作用及其在牙本质再生中的关键作用。损伤的牙髓成纤维细胞分泌的生长因子参与了祖细胞的激活和分化以及新生血管的形成，这可能为祖细胞的迁移铺平了道路。这似乎是第一篇关注牙髓生物学中这一非常重要的领域的论文。
The elaboration of dentin-pulp engineering strategies requires the investigation of not only progenitor cell potentials but also their interactions with other non-progenitor "supportive" cells. Under severe caries lesions, progenitor cells may be activated by growth factors released after the acidic dissolution of carious dentin. However, dentin regeneration has also been observed after traumatic injuries without any significant dentin dissolution. This raises questions about the origin of signals involved in progenitor cell activation, migration, and differentiation. Study models such as the entire tooth culture and co-cultures of pulp and endothelial cells highlighted the role of interactions between the different pulp cell types and the pivotal role they play in dentin regeneration. Injured pulp fibroblasts secrete growth factors involved in progenitor cell activation and differentiation as well as neoangiogenesis which may pave the pathways for progenitor cell migration. This appears to be the first paper to focus on this very important field in dental pulp biology.