A theory of allelic and isotypic exclusion for immunoglobulin genes.
A theory of allelic and isotypic exclusion for immunoglobulin genes.
复制标题
免疫球蛋白基因的等位基因和同种型排除理论。
DOI：
10.1073/pnas.79.22.6976
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发表时间：
1982
影响因子：
11.1
通讯作者：
C. Steinberg
中科院分区：
文献类型：
--
作者：
M. Wabl;C. Steinberg
Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at the L chain loci, generating the complete gene which may or may not be functional. This ensures allelic and isotypic exclusion for the L chain loci. It is further proposed that those cells that productively rearrange both alleles at the H chain locus are eliminated by the "H chain toxicity" effect.
