Signaling regulations of neuronal regenerative ability.
Signaling regulations of neuronal regenerative ability.
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DOI：
10.1016/j.conb.2014.03.007
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发表时间：
2014-08
影响因子：
5.7
通讯作者：
He Z
中科院分区：
文献类型：
--
作者：
Lu Y;Belin S;He Z
与发育过程中的生理轴突生长不同，成年哺乳动物中枢神经系统（CNS）中成熟神经元的固有再生能力差是成功轴突再生的主要限制因素。近年来的研究发现了包括PTEN/mTOR、Jak/STAT、DLK/JNK在内的多条分子通路，为研究再生能力的调控机制提供了重要的探针。本文将总结这些最新的发现，并推测其影响。
Different from physiological axon growth during development, a major limiting factor for successful axon regeneration is the poor intrinsic regenerative capacity in mature neurons in the adult mammalian central nervous system (CNS). Recent studies identified several molecular pathways, including PTEN/mTOR, Jak/STAT, DLK/JNK, providing important probes in investigating the mechanisms by which the regenerative ability is regulated. This review will summarize these recent findings and speculate their implications.