Bone Abnormal Signal Incidentally Found in Pre-Biopsy Diffusion-Weighted MRI for Suspected Prostate Cancer: What Does It Reflect?
Bone Abnormal Signal Incidentally Found in Pre-Biopsy Diffusion-Weighted MRI for Suspected Prostate Cancer: What Does It Reflect?
复制标题
疑似前列腺癌活检前扩散加权 MRI 意外发现骨异常信号：反映了什么？
作者：
Yuki Yachida;S. Yoshida;H. Takeshita;Chigusa Sawamura;Hiroshi Tanaka;S. Satoh;Y. Uchida;J. Ishioka;Y. Matsuoka;N. Numao;F. Koga;K. Saito;Y. Fujii;K. Kihara
目的：阐明疑似前列腺癌患者活检前MRI偶然发现弥散加权MRI（DW-MRI）阳性结果的临床意义。患者和方法：754例疑似前列腺癌的连续患者接受了盆腔MRI，包括DW-MRI。27例患者中发现43个DW-MRI阳性骨病变。将这些病变的影像学表现与临床诊断进行比较。结果：在43个DW-MRI阳性骨病灶中，21个（48.8%）被诊断为转移性前列腺癌。其余22例（51.2%）诊断为红骨髓17例，内生软骨瘤1例，神经节瘤1例，骨瘤1例，骨纤维异常增殖症1例，骨梗死1例。内生软骨瘤、神经节瘤、骨瘤和骨纤维异常增殖症均表现为T1 WI低信号和T2 WI高信号，其他肿瘤包括前列腺癌转移瘤均表现为T1 WI和T2 WI低信号。在T1 WI和T2 WI低信号的40个病灶中，转移性前列腺癌的表观扩散系数值（中位数为0.42 × 10-3 mm 2/s）高于其他病灶（0.26 × 10- 3 mm 2/s; p < 0.0001）。结论：DW-MRI阳性骨病变代表各种共存类型的骨病变，包括疑似前列腺癌患者的转移癌。T2 WI表现和表观扩散系数值对转移癌的诊断有一定的帮助。
Objective: To clarify the clinical significance of incidentally found diffusion-weighted MRI (DW-MRI)-positive findings on pre-biopsy MRI in patients with suspected prostate cancer. Patients and Methods: 754 consecutive patients with suspected prostate cancer underwent pelvic MRI including DW-MRI. 43 DW-MRI-positive bone lesions were found in 27 patients. Imaging findings of these lesions were compared with the clinical diagnosis. Results: Of the 43 DW-MRI-positive bone lesions, 21 (48.8%) were diagnosed as metastatic prostate cancer. The remaining 22 (51.2%) were diagnosed as red bone marrow in 17, enchondroma in 1, ganglion in 1, osteoma in 1, fibrous dysplasia in 1 and bone infarction in 1. Enchondroma, ganglion, osteoma and fibrous dysplasia all showed T1-weighted imaging (T1WI) low and T2-weighted imaging (T2WI) high signals, while others, including prostate cancer metastases, showed T1WI and T2WI low signals. Of the 40 lesions with T1WI and T2WI low signals, metastatic prostate cancer had higher apparent diffusion coefficient values (median 0.42 × 10-3 mm2/s) than other lesions (0.26 × 10-3 mm2/s; p < 0.0001). Conclusions: DW-MRI-positive bone lesions represent various coexisting types of bone lesions, including metastatic cancer in patients with suspected prostate cancer. T2WI findings and apparent diffusion coefficient values can be helpful in diagnosing metastatic cancer.
影响因子：
158.5
作者：
Petrylak, DP;Tangen, CM;Crawford, ED
通讯作者：
Crawford, ED
影响因子：
4.8
作者：
通讯作者：
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影响因子：
23.4
作者：
Sonn, Geoffrey A.;Chang, Edward;Natarajan, Shyam;Margolis, Daniel J.;Macairan, Malu;Lieu, Patricia;Huang, Jiaoti;Dorey, Frederick J.;Reiter, Robert E.;Marks, Leonard S.
通讯作者：
Marks, Leonard S.