Vasopressin receptors in the mouse (Mus musculus) brain: Sex-related expression in the medial preoptic area and hypothalamus
Vasopressin receptors in the mouse (Mus musculus) brain: Sex-related expression in the medial preoptic area and hypothalamus
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DOI：
10.1016/s0006-8993(96)01019-0
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发表时间：
1996-12-16
期刊：
影响因子：
2.9
通讯作者：
deBilbao, F
中科院分区：
文献类型：
--
作者：
DuboisDauphin, M;Barberis, C;deBilbao, F
我们利用放射性碘配体和胶片放射自显影技术研究了加压素结合位点在雄性和雌性成年小鼠大脑中的分布。抗利尿激素受体在大脑的不同区域被发现，包括梅纳特基底核、无名物质、下丘脑室旁核、黑质致密部和舌下核。抗利尿激素受体的表达在大鼠性二形核对应的内侧视前区/下丘脑前部和下丘脑乳头核中存在性别差异。在这两种结构中，女性的放射自显影标记比男性更强烈。这些观察结果证实，到目前为止，大多数物种的下丘脑视前区存在抗利尿激素结合位点，神经肽受体的性别相关表达可能引发与性别相关的行为差异。
We have investigated the distribution of vasopressin binding sites in the brain of male and female adult mice using a radio-iodinated ligand and film autoradiography. Vasopressin receptors were uncovered in various regions of the brain including the basal nucleus of Meynert, the substantia innominata, the hypothalamic paraventricular nucleus, the substantia nigra pars compacta and the hypoglossal nucleus. A sex-related difference in the expression of vasopressin receptors was seen in the medial preoptic area/anterior hypothalamus corresponding to the rat sexually dimorphic nucleus in the rat and in the hypothalamic mammillary nuclei. In both structures the autoradiographic labeling is more intense in females than in males. These observations confirm that vasopressin binding sites are present in the hypothalamic preoptic area of most species examined so far and that sex-related expression of neuropeptide receptors could trigger sex-related behavioral differences.