Curcumin acts via transient receptor potential vanilloid‐1 receptors to inhibit gut nociception and reverses visceral hyperalgesia
Curcumin acts via transient receptor potential vanilloid‐1 receptors to inhibit gut nociception and reverses visceral hyperalgesia
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DOI：
10.1111/nmo.12145
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发表时间：
2013-06
影响因子：
3.5
通讯作者：
L. Zhi;Li Dong;D. Kong;Biying Sun;Q. Sun;David Grundy;G. Zhang;Weifang Rong
中科院分区：
文献类型：
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作者：
L. Zhi;Li Dong;D. Kong;Biying Sun;Q. Sun;David Grundy;G. Zhang;Weifang Rong
姜黄素在动物模型和人类中具有抗伤害感受作用，但姜黄素作用的分子机制仍不明确。在这项研究中，我们探讨了姜黄素通过拮抗瞬时受体电位香草酸-1（TRPV 1）受体抑制内脏伤害性感受的可能性。
An antinociceptive effect has been reported for curcumin in animal models and in humans, but the molecular mechanisms of curcumin's effect remain undefined. In this study, we explored the possibility that curcumin inhibit visceral nociception via antagonizing the transient receptor potential vanilloid‐1 (TRPV1) receptor.