Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy
Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy
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DOI：
10.1016/j.earlhumdev.2010.05.010
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发表时间：
2010-06-01
影响因子：
2.5
通讯作者：
Badawi, Nadia
中科院分区：
文献类型：
--
作者：
Kurinczuk, Jennifer J.;White-Koning, Melanie;Badawi, Nadia
新生儿脑病(NE)是新生儿脑功能紊乱的临床表现。缺乏对NE和缺氧缺血亚组(HIE)的普遍认可的定义，使得发病率的估计和危险因素的识别成为问题。新生儿脑炎发病率估计为每1000名活产儿中3.0例(95%可信区间2.7至3.3)，缺氧缺血性脑病发病率为1.5例(95%可信区间1.3至1.7)。在发达国家和发展中国家，NE的危险因素不同，前者生长受限最严重，后者双胞胎妊娠最严重。潜在的可改变的风险因素包括产妇甲状腺疾病、接受产前护理、感染以及分娩和分娩管理的各个方面，尽管一些干预措施的适应症没有报告，可能是对胎儿损害的反应，而不是原因。据估计，在发达人群中有30%的NE病例和在发展中人群中有60%的病例有一些产中缺氧缺血的证据。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Neonatal encephalopathy (NE) is the clinical manifestation of disordered neonatal brain function. Lack of universal agreed definitions of NE and the sub-group with hypoxic-ischaemia (HIE) makes the estimation of incidence and the identification of risk factors problematic. NE incidence is estimated as 3.0 per 1000 live births (95%Cl 2.7 to 3.3) and for HIE is 1.5 (95%Cl 1.3 to 1.7). The risk factors for NE vary between developed and developing countries with growth restriction the strongest in the former and twin pregnancy in the latter. Potentially modifiable risk factors include maternal thyroid disease, receipt of antenatal care, infection and aspects of the management of labour and delivery, although indications for some interventions were not reported and may represent a response to fetal compromise rather than the cause. It is estimated that 30% of cases of NE in developed populations and 60% in developing populations have some evidence of intrapartum hypoxic-ischaemia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.