Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage
Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage
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DOI：
10.1097/01.pas.0000157940.80538.ec
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发表时间：
2005-05-01
影响因子：
5.6
通讯作者：
Natkunam, Y
中科院分区：
文献类型：
--
作者：
Nguyen, TDT;Schwartz, EJ;Natkunam, Y
CD 163是一种血红蛋白清道夫受体，在单核细胞和巨噬细胞中表达。我们使用组织微阵列和常规石蜡包埋组织切片检测了1105例人类恶性肿瘤和正常组织中CD 163蛋白的表达。除了对非肿瘤性单核细胞和组织细胞（组织巨噬细胞）进行染色外，CD 163的膜/胞质染色主要限于具有单核细胞/组织细胞分化的肿瘤。在正常组织、淋巴瘤、癌和大多数间充质肿瘤（包括滤泡树突状细胞肿瘤）中未观察到CD 163反应性（0/4），尽管其染色混合的组织细胞。在Rosai-Dorfman病（5/6）、组织细胞肉瘤（3/4）、沿岸的细胞血管瘤（6/6）和朗格汉斯细胞组织细胞增生症（3/5）中观察到CD 163染色。非典型纤维组织细胞瘤（9/16）、良性纤维组织细胞瘤（6/9）和非典型纤维黄色瘤（1/3）也显示出CD 163染色。我们的研究还证实了早期的工作，即CD 163在急性髓性白血病单核细胞分化（AML，FAB亚型M5）（2/6）以及大多数巨细胞腱鞘瘤（7/8）中表达。其有限的表达范围和组织特异性表明，CD 163可能具有显着的诊断效用，从其他实体中分离单核细胞和组织细胞来源的特定肿瘤的鉴别诊断。
CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages. We tested the expression of the CD 163 protein in 1, 105 human malignancies and normal tissues using tissue microarrays and conventional paraffin-embedded tissue sections. Besides staining nonneoplastic monocytes and histiocytes (tissue macrophages), membranous/cytoplasmic staining for CD163 was primarily limited to neoplasms with morrocytic/histiocytic differentiation. CD163 reactivity was not observed in normal tissues, lymphomas, carcinomas, and in a majority of mesenchymal neoplasms, including follicular dendritic cell tumors (0 of 4), although it stained admixed histiocytes. Staining for CD 163 was seen in Rosai-Dorfman disease (5 of 6), histiocytic sarcoma (3 of 4), littoral cell angioma (6 of 6), and Langerhans cell histiocytosis (3 of 5). A subset of atypical fibrous histiocytomas (9 of 16), benign fibrous histiocytomas (6 of 9), and atypical fibroxanthomas (I of 3) also showed CD163 staining. Our studies also confirm earlier work showing that CD163 is expressed in acute myeloid leukemia with monocytic differentiation (AML, FAB subtype M5) (2 of 6), as well as a majority of giant cell tenosynovial tumors (7 of 8). Its limited range of expression and tissue specificity indicate that CD 163 may have significant diagnostic utility in separating specific tumors with monocytic and histiocytic derivation from other entities in their differential diagnosis.