BRCA1, hormone, and tissue-specific tumor suppression.
BRCA1, hormone, and tissue-specific tumor suppression.
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DOI：
10.7150/ijbs.5.20
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发表时间：
2009
影响因子：
9.2
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Hu Y
Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.
