Anticentriole antibody in a patient with progressive systemic sclerosis.
Anticentriole antibody in a patient with progressive systemic sclerosis.
复制标题
进行性系统性硬化症患者的抗中心粒抗体。
DOI：
10.1002/art.1780290120
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发表时间：
1986
影响因子：
--
通讯作者：
Moore,TL
中科院分区：
文献类型：
--
作者：
Osborn,TG;Ryerse,JS;Bauer,NE;Urhahn,JM;Blair,D;Moore,TL
Various antinuclear antibody (ANA) patterns have been described in progressive systemic sclerosis (PSS)(I). These include homogeneous, nucleolar, speckled, and discrete speckled patterns (2). Immunofluorescence microscopy with various tissue culture substrates has permitted more defined localization of antibody targets. This study characterizes a serum autoantibody from a patient with PSS. By immunoelectron microscopy, the specificity of the antibody was localized to the centriolar structures of the cell. Tlhis distinguished it from possible activity against mitotic spindle components or other surrounding fibrillar structures.
