A low albumin to globulin ratio with a high serum globulin level is a prognostic marker for poor survival in cervical cancer patients treated with radiation based therapy
A low albumin to globulin ratio with a high serum globulin level is a prognostic marker for poor survival in cervical cancer patients treated with radiation based therapy
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DOI：
10.1136/ijgc-2018-000025
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发表时间：
2019-01-01
影响因子：
4.8
通讯作者：
Yasugi, Toshiharu
中科院分区：
文献类型：
--
作者：
Yoshino, Yasunori;Taguchi, Ayumi;Yasugi, Toshiharu
目的探讨放射治疗前白蛋白/球蛋白比值、血清白蛋白水平和血清球蛋白水平能否预测宫颈癌放射治疗患者的生存时间，并评估球蛋白含量。评估治疗前白蛋白/球蛋白比率、血清白蛋白和球蛋白水平与总存活率的关系。结果中位随访时间为30个月(智商16~44个月)。低白蛋白/球蛋白比值是影响总生存率的独立预后因素(HR=3.07；95%CI为1.03~13.3；P=0.044)。在分别评估血清球蛋白和白蛋白时，高血清球蛋白水平与总生存期显著相关(截断值2.9g/dL；HR=3.74；95%CI1.08~23.6；P=0.036)，而低血清白蛋白水平与总生存期无关(截断值3.6g/dL；HR=1.77；95%CI0.57~4.54；P=0.29)。血清蛋白的电泳图显示-球蛋白含量与球蛋白水平的相关性最强(P
Objective We investigated whether the pretreatment albumin to globulin ratio, serum albumin level, and serum globulin level can be used to predict survival among cervical cancer patients treated with radiation based therapy and assessed globulin fractions.Methods We retrospectively enrolled 128 patients with cervical cancer treated with radiation based therapy at our institution between 2010 and 2015. The associations of the pretreatment albumin to globulin ratio, and serum albumin and globulin levels with overall survival were assessed. Additionally, the associations of the globulin fractions with the serum globulin levels and overall survival were evaluated.Results Median follow-up duration was 30 months (IQR 16-44 months). A low albumin to globulin ratio (< 1.53) was found to be an independent prognostic factor for overall survival (HR= 3.07; 95% CI, 1.03 to 13.3; P=0.044). On evaluating serum globulin and albumin separately, a high serum globulin level was significantly associated with overall survival (cut-off value 2.9g/dL; HR=3.74; 95%CI 1.08 to 23.6; P=0.036) whereas a low serum albumin level was not associated with overall survival (cut-off value 3.6 g/dL; HR=1.77; 95% CI 0.57 to 4.54; P=0.29). Electrophoresis data of the serum proteins revealed that the -globulin fraction was most strongly correlated with the globulin levels (P