Inflammatory mechanisms: The molecular basis of inflammation and disease
Inflammatory mechanisms: The molecular basis of inflammation and disease
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DOI：
10.1111/j.1753-4887.2007.tb00352.x
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发表时间：
2007-12-01
影响因子：
6.1
通讯作者：
Libby, Peter
中科院分区：
文献类型：
--
作者：
Libby, Peter
炎症重要地参与宿主对感染因子和损伤的防御，但它也有助于许多慢性疾病的病理生理学。先天免疫系统、适应性免疫系统和炎症介质中细胞的相互作用协调了许多器官疾病的急性和慢性炎症的各个方面。一系列协调的常见炎症效应机制有助于不同靶组织中的组织损伤、氧化应激、细胞外基质重塑、血管生成和纤维化。动脉粥样硬化提供了一个涉及炎症机制的慢性疾病的例子。血液白细胞的募集是这种疾病发生的特征。其进展涉及许多炎症介质，由先天性和适应性免疫细胞调节。已形成的动脉粥样硬化的并发症，包括斑块破裂和血栓形成，也与炎症密切相关。掌握炎症反应应该有助于开发新的策略来预测疾病易感性，靶向和监测治疗，并最终开发新的方法来预防和治疗与衰老相关的慢性疾病，如动脉粥样硬化。
Inflammation participates importantly in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of many chronic diseases. Interactions of cells in the innate immune system, adaptive immune system, and inflammatory mediators orchestrate aspects of the acute and chronic inflammation that underlie diseases of many organs. A coordinated series of common effector mechanisms of inflammation contribute to tissue injury, oxidative stress, remodeling of the extracellular matrix, angiogenesis, and fibrosis in diverse target tissues. Atherosclerosis provides an example of a chronic disease that involves inflammatory mechanisms. Recruitment of blood leukocytes characterizes the initiation of this disease. Its progression involves many inflammatory mediators, modulated by cells of both innate and adaptive immunity. The complications of established atheroma, including plaque disruption and thrombosis, also intimately involve inflammation. Mastery of the inflammatory response should aid the development of novel strategies to predict disease susceptibility, target and monitor therapies, and ultimately develop new approaches to the prevention and treatment of chronic diseases associated with aging, such as atherosclerosis.