THE ROLE OF SIGA+B CELLS IN ORAL IMMUNITY
THE ROLE OF SIGA+B CELLS IN ORAL IMMUNITY
复制标题
DOI：
10.1111/j.1749-6632.1995.tb44446.x
复制
发表时间：
1995-01-01
期刊：
影响因子：
--
通讯作者：
STROBER, W
中科院分区：
文献类型：
--
作者：
EHRHARDT, RO;STROBER, W
粘膜免疫系统和中枢免疫系统之间的差异从未得到比白细胞介素和TCR基因转导小鼠的情况更好的证明，其中IG 2或IL-10或α T细胞的缺乏导致广泛的粘膜炎症，而中枢免疫区域没有任何显著的炎症。这些非常重要的发现清楚地表明，粘膜免疫系统的调节与中枢免疫系统不同。因此，我们能够预测口服抗原的三个主要结果：局部免疫应答、具有体液和细胞免疫的全身免疫应答以及全身耐受性（口服耐受性）。虽然很明显，强烈的口服免疫应答伴随着伊加抗体应答，但伊加应答的质量是否可用作粘膜免疫应答结果的预测标志物仍存在很大争议，因为口服耐受动物中粘膜免疫应答的状态非常不清楚。因此，为了了解是什么决定了口服抗原激发的结果，研究T和B细胞在其自然环境中的反应是非常关键的，例如，派伊尔集合淋巴结。这对于当前口服疫苗研究克服口服耐受的诱导和实现强而持久的免疫应答尤其重要。我们实验室的工作已经聚焦于粘膜B细胞分化（特别是sIgA+ B细胞分化），因此本文综述了该领域的最新进展。讨论了与确定sIgM+ B细胞变为sIgA+ B细胞（sIgA+ B细胞转换分化）的事件相关的发现，以及进一步阐明我们实验室最近与终末B细胞分化相关的发现。
The difference between the mucosal immune system and the central immune system has never been better demonstrated than in the case of interleukin and TCR gene-talgeted mice, where the absence of IG2 or IL-10 or alphabeta T cells leads to extensive mucosal inflammation in the absence of any significant inflammation of the central immune areas.'+ These very important findings indicate clearly that the mucosal immune system is regulated differently from the central immune system. Thus fir we are able to predict three major outcomes of an oral administration of antigen: a local immune response, a systemic immune response with humoral and cellular immunity, and a systemic tolerance (oral tolerance). While it is very clear that a strong oral immune response is accompanied by an IgA antibody response, it is still very controversial whether the quality of an IgA response can be used as a predictive marker for the outcome of a mucosal immune response, since the status of the mucosal immune response in orally tolerized animals is very unclear. Thus, to understand what determines the outcome of an oral antigenic challenge, it is very crucial to study T and B cell responses in its natural environment, eg, Peyer's patch. This is especially important for current oral vaccine research in its effort to overcome the induction of oral tolerance and accomplish strong and long-lasting immune responses. The work in our laboratory has been focusing fbr several years now on mucosal B cell differentiation (in particular sIgA+ B cell differentiation), and therefore this review summarizes current insights into this field. The findings relating to the events that de-termine that a sIgM+ B cell becomes a sIgA+ B cell (sIgA+ B cell switch differentiation) are discussed as well as the further elucidation of recent findings in our laboratory relating to terminal B cell differentiation.