Increased plasma levels of Urotensin-II in preeclampsia-eclampsia: a new mediator in pathogenesis?
Increased plasma levels of Urotensin-II in preeclampsia-eclampsia: a new mediator in pathogenesis?
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DOI：
10.1016/j.ejogrb.2004.07.029
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发表时间：
2005-05-01
影响因子：
2.6
通讯作者：
Anarat, R
中科院分区：
文献类型：
--
作者：
Balat, O;Aksoy, F;Anarat, R
目的：探讨人尿紧张素- ii （hU-II）可能的作用。一种血管活性肽，在子痫前期的病理生理中具有前瞻性。研究设计：选取2002年1月至2002年12月住院的60例患者，其中30例诊断为子痫前期子痫（I组），30例对照（II组）。I组患者妊娠28周后血压升高，无高血压病史和/或先兆子痫或子痫。使用放射免疫分析法评估hU-II水平。结果：组间年龄、胎龄、妊娠、流产、胎次比较，差异均无统计学意义（P < 0.05）。子痫前期-子痫组和对照组血浆hU-II水平分别为10.11 +/- 5.94 pg/mL和3.93 +/- 1.73 pg/mL。两组患者血浆hU-II水平差异有统计学意义（P < 0.00001）。两组患者hU-II水平与平均动脉压存在相关性（r = 0.73, P < 0.0001； I组和It组r = 0.72, P < 0.0001）。结论：我们的研究结果强烈提示hU-II在子痫前期-子痫的病理生理中起重要作用。Furthcr。关于胎盘和脐带血样本的研究将更清楚地阐明尿紧张素- ii在子痫前期-子痫发病机制中的作用及其对胎母的影响。(c) 2004年由爱思唯尔爱尔兰有限公司出版
Objective: To assess the possible role of human Urotensin-II (hU-II). a vasoactive peptide, in the pathophysiology of preeclampsia-eclampsia prospectively.Study design: Sixty subjects, 30 with a diagnosis of preeclampsia-eclampsia (group I) and 30 control subjects (group II), who had been admitted between January, 2002 and December, 2002, were taken into the study. Patients in group I had an increase in blood pressure after 28th week of gestation, without any history of hypertensive disease and/or preeclampsia or eclampsia. hU-II levels were assessed using a radioimmununoassay method.Results: No statistically significant difference in terms of age, gestational age, gravidity, abortion and parity was detected among groups (P > 0.05). Plasma hU-II levels in the preeclampsia-eclampsia and control groups were 10.11 +/- 5.94 pg/mL and 3.93 +/- 1.73 pg/mL, respectively. Difference between plasma hU-II levels of the two groups was found to be statistically significant (P < 0.00001). Also there was correlation between hU-II levels and mean arterial pressures in both groups (r = 0.73, P < 0.0001 and r = 0.72, P < 0.0001 for groups I and It, respectively).Conclusion: Results of our study strongly suggest an important role for hU-II in the pathophysiology of preeclampsia-eclampsia. Furthcr. studies concerning placenta and cord blood samples will more clearly elucidate the role of Urotensin-II in the pathogenesis of preeclampsia-eclampsia, and its feto-maternal effects. (c) 2004 Published by Elsevier Ireland Ltd.