Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma.
Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma.
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Interleukin-12 诱导的小鼠乳腺癌抑制中的基因表达分析。
DOI：
10.1002/ijc.20145
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发表时间：
2004
影响因子：
6.4
通讯作者：
Ma,Xiaojing
中科院分区：
文献类型：
--
作者：
Shi,Xiaoyan;Liu,Jianguo;Xiang,Zhaoying;Mitsuhashi,Maki;Wu,RitaS;Ma,Xiaojing
白细胞介素-12（IL-12）通过天然杀伤细胞和细胞毒性T淋巴细胞具有强大的抗肿瘤活性。然而，IL-12诱导杀肿瘤活性的分子机制知之甚少。在这里，我们报告了在类似于人乳腺癌的原发性小鼠乳腺癌模型中的基因表达的全基因组分析，在重组IL-12的治疗应用后，限制了肿瘤的生长和转移。IL-12能够减少肿瘤中的新血管形成，并增加肿瘤浸润淋巴细胞的数量。对整体基因表达的全面检查揭示了IL-12诱导的与肿瘤消退和肺转移减少相关的分子变化，从而提供了宿主对正在发展的恶性肿瘤的反应的高分辨率快照，以及乳腺癌治疗干预的潜在靶点的丰富来源。© 2004 Wiley利斯公司
Interleukin‐12 (IL‐12) has potent antitumor activitiesvianatural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL‐12 induces tumoricidal activities are poorly understood. Here, we report the genome‐wide analysis of gene expression in a primary murine mammary carcinoma model that resembles human breast cancer, following the therapeutic application of recombinant IL‐12, which restricted tumor growth and metastasis. IL‐12 was able to curtail neovascularization in the tumor as well as enhance the number of tumor‐infiltrating lymphocytes. Comprehensive examination of global gene expression revealed IL‐12‐induced molecular changes associated with tumor regression and reduced lung metastasis, thus providing a high‐resolution snapshot of a host response against a developing malignancy and a rich source of potential targets for therapeutic intervention of breast cancer. © 2004 Wiley‐Liss, Inc.